3-BROMO-5-METHYLPHENYLBORONIC ACID - Names and Identifiers
3-BROMO-5-METHYLPHENYLBORONIC ACID - Physico-chemical Properties
Molecular Formula | C7H8BBrO2
|
Molar Mass | 214.85 |
Density | 1.57±0.1 g/cm3(Predicted) |
Melting Point | 278-283°C(lit.) |
Boling Point | 351.8±52.0 °C(Predicted) |
Flash Point | 166.566°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 7.65±0.10(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Refractive Index | 1.585 |
3-BROMO-5-METHYLPHENYLBORONIC ACID - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Safety Description | S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
|
WGK Germany | 3 |
Hazard Note | Irritant/Keep Cold |
3-BROMO-5-METHYLPHENYLBORONIC ACID - Introduction
(3-bromo-5-methylphenyl)boronic acid is an organic compound with the chemical formula C7H8BBrO2. Here are some information about its nature, use, formulation and safety:
Nature:
-Appearance: Colorless or light yellow solid.
-Melting point: about 140°C.
-Solubility: Soluble in organic solvents such as dichloromethane, ethanol and ether, slightly soluble in water.
-Stability: Stable at room temperature.
Use:
-Catalyst:(3-bromo-5-methylphenyl)boronic acid is widely used as a catalyst for organic synthesis reactions.
-Drug intermediates: It can also be used to prepare intermediates for drugs and other organic compounds.
-Research use: Because it is very valuable for the application of coordination chemistry, it is widely used in coordination chemistry and coordination polymer research.
Preparation Method:
(3-bromo-5-methylphenyl)boronic acid can be prepared by the following steps:
1. Add (3-bromo-5-methylphenyl)boronic acid benzyl ester (3-bromo-5-methyl benzeneboronic acid methyl ester) to the reaction solvent.
2. Add boric acid (boronic acid) or other boric acid reagents, such as triphenyl boric acid (triphenylboronic acid). The reaction produces (3-bromo-5-methylphenyl)boronic acid.
Safety Information:
- (3-bromo-5-methylphenyl)boronic acid has no obvious safety hazards under normal use conditions.
-but still need to pay attention to the traditional laboratory safety operation.
-Avoid contact with skin and eyes and use personal protective equipment if necessary.
-It should be operated in a well-ventilated place to avoid inhaling dust or gas.
-Wash your hands thoroughly before eating or smoking. After operation, waste is carefully disposed of and disposed of in compliance with relevant regulations.
Please note that the chemical properties and safety information is based on existing knowledge and research results, but specific applications and operations still need to be evaluated and controlled based on actual conditions. When using chemicals, follow proper laboratory practices and safe practices.
Last Update:2024-04-09 21:04:16